Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 12 (24)

Mechanisms of Bioactive Glass on Caries Management: A Review


Mechanisms of Bioactive Glass on Caries Management: A Review

Lin Lu Dai et al. Materials (Basel).


This review investigates the mechanisms of bioactive glass on the management of dental caries. Four databases (PubMed, Web of Science, EMBASE (via Ovid), Medline (via Ovid)) were systematically searched using broad keywords and terms to identify the literature pertaining to the management of dental caries using "bioactive glass". Titles and abstracts were scrutinized to determine the need for full-text screening. Data were extracted from the included articles regarding the mechanisms of bioactive glass on dental caries management, including the aspect of remineralizing effect on enamel and dentine caries, and antimicrobial effect on cariogenic bacteria. After removal of duplicates, 1992 articles were identified for screening of the titles and abstracts. The full texts of 49 publications were scrutinized and 23 were finally included in this review. Four articles focused on the antimicrobial effect of bioactive glass. Twelve papers discussed the effect of bioactive glass on demineralized enamel, while 9 articles investigated the effect of bioactive glass on demineralized dentine. In conclusion, bioactive glass can remineralize caries and form apatite on the surface of enamel and dentine. In addition, bioactive glass has an antibacterial effect on cariogenic bacteria of which may help to prevent and arrest dental caries.

Keywords: bioactive glass; caries; mechanism; review.

Conflict of interest statement

The authors declare no conflict of interests.


Figure 1
Figure 1
Flowchart of literature search of bioactive glass.
Figure 2
Figure 2
SEM images of the morphology of demineralized dentine: (a) 10,000× magnification image of demineralized dentine treated with bioactive glass; (b) 10,000× magnification image of demineralized dentine without treatment with bioactive glass.

Similar articles

See all similar articles


    1. Kutsch V.K. Dental caries: An updated medical model of risk assessment. J. Prosthet. Dent. 2014;111:280–285. doi: 10.1016/j.prosdent.2013.07.014. - DOI - PubMed
    1. Pitts N.B., Zero D.T., Marsh P.D., Ekstrand K., Weintraub J.A., Ramos-Gomez F., Tagami J., Twetman S., Tsakos G., Ismail A. Dental caries. Nat. Rev. Dis. Primers. 2017;3:17030. doi: 10.1038/nrdp.2017.30. - DOI - PubMed
    1. Wong A., Subar P.E., Young D.A. Dental Caries: An Update on Dental Trends and Therapy. Adv. Pediatr. 2017;64:307–330. doi: 10.1016/j.yapd.2017.03.011. - DOI - PubMed
    1. Schwendicke F., Frencken J.E., Bjorndal L., Maltz M., Manton D.J., Ricketts D., Van Landuyt K., Banerjee A., Campus G., Domejean S., et al. Managing Carious Lesions: Consensus Recommendations on Carious Tissue Removal. Adv. Dent. Res. 2016;28:58–67. doi: 10.1177/0022034516639271. - DOI - PubMed
    1. Gonzalez-Cabezas C., Fernandez C.E. Recent Advances in Remineralization Therapies for Caries Lesions. Adv. Dent. Res. 2018;29:55–59. doi: 10.1177/0022034517740124. - DOI - PubMed