MicroRNA regulation of CD8+ T cell responses

Noncoding RNA Investig. 2019 Aug;3:24. doi: 10.21037/ncri.2019.07.02. Epub 2019 Aug 26.


MicroRNAs (miRNAs) are a class of short noncoding RNAs that play critical roles in the regulation of a broad range of biological processes. Like transcription factors, miRNAs exert their effects by modulating the expression of networks of genes that operate in common or convergent pathways. CD8+ T cells are critical agents of the adaptive immune system that provide protection from infection and cancer. Here, we review the important roles of miRNAs in the regulation of CD8+ T cell biology and provide perspectives on the broader emerging principles of miRNA function.

Keywords: MicroRNA (miRNA); T cell exhaustion; T cell memory; cytotoxic T cell.