Novel topical formulation applied to the nipple-areola complex improves female orgasm

J Cosmet Dermatol. 2020 Feb;19(2):404-406. doi: 10.1111/jocd.13262. Epub 2019 Dec 17.


Background: The nipple-areola complex (NAC) is an often overlooked but important erogenous zone in the female sexual response and sexual functional repertoire. Research suggests that nipple stimulation is significant to female sexual satisfaction in as many as 80% of women. Previously, we have reported that stimulation of the arrector pili muscle in the NAC increases nipple sensitivity and has a positive impact on female sexual function.

Aims: To study the effect of RJ-101 on female orgasm.

Methods: A randomized double-blinded placebo-controlled study of RJ101, a novel topical formulation that stimulates the arrector pili muscle of the NAC, in 59 women. Each subject completed a survey composed of Likert scale questions in order to identify changes in orgasm after topical application of RJ101 or placebo.

Results: We demonstrated a positive increase in the perceived intensity of orgasm and orgasmic satisfaction/pleasure in women using RJ101 vs those in the placebo group. After 4 weeks of treatment, 76% of the women in the RJ101 arm reported a positive improvement in satisfaction with orgasm versus 47% in the placebo cohort. The mean change in score for overall satisfaction with orgasm in the RJ101 group was statistically significant (P = .007) compared to placebo.

Conclusion: The application of RJ101 to the NAC 30 minutes prior to sexual activity can improve orgasmic strength, pleasure, and satisfaction.

Keywords: breast; nipple; orgasm; sexuality.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adrenergic alpha-1 Receptor Agonists / administration & dosage*
  • Adult
  • Female
  • Humans
  • Middle Aged
  • Nipples / drug effects
  • Nipples / innervation
  • Nipples / physiology*
  • Norepinephrine / administration & dosage*
  • Orgasm / drug effects*
  • Orgasm / physiology
  • Personal Satisfaction
  • Placebos / administration & dosage


  • Adrenergic alpha-1 Receptor Agonists
  • Placebos
  • Norepinephrine