Trans-3'-hydroxycotinine--a main metabolite in smokers

Klin Wochenschr. 1988:66 Suppl 11:2-4.


Trans-3'-hydroxycotinine was found to be a main metabolite of nicotine in smokers. It is the most abundant among all nicotine metabolites, if the total urine is collected over 7 consecutive days of smoking and 5 following days without smoking. Its steady-state blood plasma concentration on the 6th day of smoking is second only to cotinine. In the experiments nine habitual smokers smoked 19 cigarettes per day on 7 days of smoking. Three runs were carried out with three types of cigarettes which differed in mainstream nicotine. After oral administration of 30 mg trans-3'-hydroxycotinine, the cumulative excretion rates of two subjects were 81% and 93% of the unchanged compound, respectively.

MeSH terms

  • Adult
  • Biotransformation
  • Cotinine / analogs & derivatives
  • Cotinine / pharmacokinetics*
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Nicotine / administration & dosage
  • Nicotine / pharmacokinetics
  • Pyrrolidinones / pharmacokinetics*
  • Smoking / urine*
  • Stereoisomerism


  • Pyrrolidinones
  • hydroxycotinine
  • Nicotine
  • Cotinine