MicroRNA dysregulation interplay with childhood abdominal tumors

Cancer Metastasis Rev. 2019 Dec;38(4):783-811. doi: 10.1007/s10555-019-09829-x.


Abdominal tumors (AT) in children account for approximately 17% of all pediatric solid tumor cases, and frequently exhibit embryonal histological features that differentiate them from adult cancers. Current molecular approaches have greatly improved the understanding of the distinctive pathology of each tumor type and enabled the characterization of novel tumor biomarkers. As seen in abdominal adult tumors, microRNAs (miRNAs) have been increasingly implicated in either the initiation or progression of childhood cancer. Moreover, besides predicting patient prognosis, they represent valuable diagnostic tools that may also assist the surveillance of tumor behavior and treatment response, as well as the identification of the primary metastatic sites. Thus, the present study was undertaken to compile up-to-date information regarding the role of dysregulated miRNAs in the most common histological variants of AT, including neuroblastoma, nephroblastoma, hepatoblastoma, hepatocarcinoma, and adrenal tumors. Additionally, the clinical implications of dysregulated miRNAs as potential diagnostic tools or indicators of prognosis were evaluated.

Keywords: Adrenal tumors; Hepatoblastoma; Hepatocarcinoma; Nephroblastoma; Neuroblastoma; miRNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Abdominal Neoplasms / genetics*
  • Abdominal Neoplasms / metabolism
  • Animals
  • Child
  • Humans
  • MicroRNAs / biosynthesis
  • MicroRNAs / genetics*


  • MicroRNAs