Anti-Hu Antibody-Associated Adie's Pupil and Paraneoplastic Sensorimotor Polyneuropathy Caused by Primary Mediastinal Small Cell Carcinoma

Lei Zhang; Si Luo; Hui Jin; Xueman Lv; Jiajun Chen

doi:10.3389/fneur.2019.01236

Anti-Hu Antibody-Associated Adie's Pupil and Paraneoplastic Sensorimotor Polyneuropathy Caused by Primary Mediastinal Small Cell Carcinoma

Front Neurol. 2019 Nov 26:10:1236. doi: 10.3389/fneur.2019.01236. eCollection 2019.

Authors

Lei Zhang¹, Si Luo¹, Hui Jin¹, Xueman Lv², Jiajun Chen¹

Affiliations

¹ Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
² Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, China.

Abstract

We report a woman with unilateral Adie's pupil associated with peripheral sensorimotor polyneuropathy, elevated anti-Hu antibody, and primary mediastinal small cell carcinoma (SCC). To our knowledge, this is the first report of Adie's pupil in a patient with mediastinal SCC. Although rare, Adie's pupil and sensorimotor polyneuropathy may be the first manifestation of cancer. Its rapid recognition facilitates an early diagnosis and treatment.

Keywords: Adie's pupil; anti-Hu antibody; paraneoplastic neurological syndrome; peripheral neuropathy; small cell carcinoma.

Publication types

Case Reports