CXCR2 Signaling and Remyelination in Preclinical Models of Demyelination

DNA Cell Biol. 2020 Jan;39(1):3-7. doi: 10.1089/dna.2019.5182. Epub 2019 Dec 17.

Abstract

The chemokine receptor CXCR2 is a receptor for CXC chemokines, including CXCL1 and CXCL2. CXCR2 is expressed by resident cells of the central nervous system, including neurons, microglia, oligodendrocyte progenitor cells (OPCs), and oligodendrocytes. CXCR2 signaling is important in regulating OPC biology with regard to positional migration and myelination during development. More recently, studies have argued that CXCR2 is involved in controlling events related to remyelination after experimentally induced demyelination. This review examines the concept that targeting CXCR2 may offer a novel therapeutic target for promoting remyelination.

Keywords: chemokine receptors; demyelination; oligodendrocyte; remyelination.

Publication types

  • Review

MeSH terms

  • Animals
  • Central Nervous System / cytology
  • Central Nervous System / metabolism*
  • Demyelinating Diseases / genetics*
  • Demyelinating Diseases / metabolism
  • Disease Models, Animal*
  • Gene Expression Regulation
  • Humans
  • Mice
  • Neurons / cytology
  • Neurons / metabolism
  • Oligodendroglia / cytology
  • Oligodendroglia / metabolism
  • Receptors, Interleukin-8B / genetics*
  • Receptors, Interleukin-8B / metabolism
  • Remyelination / genetics*
  • Signal Transduction / genetics*

Substances

  • Receptors, Interleukin-8B