Effectiveness of integrative medicine group visits in chronic pain and depressive symptoms: A randomized controlled trial

PLoS One. 2019 Dec 18;14(12):e0225540. doi: 10.1371/journal.pone.0225540. eCollection 2019.

Abstract

Background: Current treatment options for chronic pain and depression are largely medication-based, which may cause adverse side effects. Integrative Medical Group Visits (IMGV) combines mindfulness techniques, evidence based integrative medicine, and medical group visits, and is a promising adjunct to medications, especially for diverse underserved patients who have limited access to non-pharmacological therapies.

Objective: Determine the effectiveness of IMGV compared to a Primary Care Provider (PCP) visit in patients with chronic pain and depression.

Design: 9-week single-blind randomized control trial with a 12-week maintenance phase (intervention-medical groups; control-primary care provider visit).

Setting: Academic tertiary safety-net hospital and 2 affiliated federally-qualified community health centers.

Participants: 159 predominantly low income racially diverse adults with nonspecific chronic pain and depressive symptoms.

Interventions: IMGV intervention- 9 weekly 2.5 hour in person IMGV sessions, 12 weeks on-line platform access followed by a final IMGV at 21 weeks.

Measurements: Data collected at baseline, 9, and 21 weeks included primary outcomes depressive symptoms (Patient Health Questionnaire 9), pain (Brief Pain Inventory). Secondary outcomes included pain medication use and utilization.

Results: There were no differences in pain or depression at any time point. At 9 weeks, the IMGV group had fewer emergency department visits (RR 0.32, 95% CI: 0.12, 0.83) compared to controls. At 21 weeks, the IMGV group reported reduction in pain medication use (Odds Ratio: 0.42, CI: 0.18-0.98) compared to controls.

Limitations: Absence of treatment assignment concealment for patients and disproportionate group attendance in IMGV.

Conclusion: Results demonstrate that low-income racially diverse patients will attend medical group visits that focus on non-pharmacological techniques, however, in the attention to treat analysis there was no difference in average pain levels between the intervention and the control group.

Trial registration: clinicaltrials.gov NCT02262377.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Academic Medical Centers / organization & administration
  • Adult
  • Aged
  • Aged, 80 and over
  • Chronic Pain / diagnosis
  • Chronic Pain / psychology
  • Chronic Pain / therapy*
  • Community Health Centers / organization & administration
  • Depression / diagnosis
  • Depression / psychology
  • Depression / therapy*
  • Female
  • Humans
  • Integrative Medicine / methods*
  • Integrative Medicine / organization & administration
  • Male
  • Middle Aged
  • Mindfulness / methods*
  • Office Visits*
  • Pain Measurement
  • Patient Health Questionnaire
  • Primary Health Care / methods
  • Primary Health Care / organization & administration
  • Safety-net Providers / organization & administration
  • Severity of Illness Index
  • Single-Blind Method
  • Tertiary Care Centers / organization & administration
  • Treatment Outcome
  • Young Adult

Associated data

  • ClinicalTrials.gov/NCT02262377