Frequent false-negative FIP1L1-PDGFRA FISH analyses of bone marrow samples from clonal eosinophilia at diagnosis

Br J Haematol. 2020 Mar;188(5):e76-e79. doi: 10.1111/bjh.16340. Epub 2019 Dec 18.

Authors

Linda Olsson-Arvidsson¹, Anna Norberg², Helene Sjögren³, Bertil Johansson^{1

4}

Affiliations

¹ Department of Clinical Genetics and Pathology, Division of Laboratory Medicine, Skane University Hospital, Lund, Sweden.
² Medical Biosciences, Medical and Clinical Genetics, Umeå University, Umeå, Sweden.
³ Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
⁴ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.

PMID: 31854104
DOI: 10.1111/bjh.16340

No abstract available

Keywords: FIP1L1-PDGFRA; clonal eosinophilia; false negativity; fluorescence in situ hybridisation; routine diagnostics.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Bone Marrow*
Eosinophilia*
Humans
Oncogene Proteins, Fusion
Receptor, Platelet-Derived Growth Factor alpha
mRNA Cleavage and Polyadenylation Factors

Substances

Oncogene Proteins, Fusion
mRNA Cleavage and Polyadenylation Factors
FIP1L1-PDGFRA fusion protein, human
Receptor, Platelet-Derived Growth Factor alpha

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