Viral myb oncogene encodes a sequence-specific DNA-binding activity

Nature. 1988 Oct 27;335(6193):835-7. doi: 10.1038/335835a0.


The retroviral oncogene v-myb and its cellular progenitor c-myb encode nuclear DNA-binding proteins. Myb genes have been identified in a broad range of species, including vertebrates, the fruit fly Drosophila melanogaster and the plant Zea mays. The localization of the DNA-binding domain of the v-MYB protein to the highly conserved amino-terminal region suggests that the MYB/DNA interaction is important for MYB function. We show here that v-MYB specifically recognizes the nucleotide sequence pyAACG/TG. So like other nuclear transforming proteins, v-MYB seems to be a member of the class of sequence-specific DNA-binding factors presumably involved in gene regulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Binding Sites
  • Cloning, Molecular
  • DNA / metabolism*
  • DNA-Binding Proteins / genetics*
  • Molecular Sequence Data
  • Oncogene Proteins v-myb
  • Oncogenes*
  • Plasmids
  • Retroviridae Proteins / genetics*


  • DNA-Binding Proteins
  • Oncogene Proteins v-myb
  • Retroviridae Proteins
  • DNA