Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Feb;46(1):73-85.
doi: 10.1111/nan.12591. Epub 2020 Jan 7.

Invited Review: Emerging Functions of Histone H3 Mutations in Paediatric Diffuse High-Grade Gliomas

Affiliations
Free PMC article
Review

Invited Review: Emerging Functions of Histone H3 Mutations in Paediatric Diffuse High-Grade Gliomas

L H Kasper et al. Neuropathol Appl Neurobiol. .
Free PMC article

Abstract

Paediatric diffuse high-grade gliomas (pHGG) are rare, but deadly tumours. The discovery of recurrent mutations in the tail of histone H3, changing lysine 27 to methionine, or glycine 34 to arginine or valine, has illuminated a critical role for epigenetic dysregulation in the aetiology of childhood gliomas and opened new avenues of exploration that have resulted in numerous advances for the field. In this review, we describe the current models of H3K27M mutant cancer that are available to the research community and the insights they have provided on tumour biology and the epigenetic and transcriptional effects of histone mutations. We also review the current understanding of the H3G34R/V mutation and the therapeutic outlook for the treatment of pHGG.

Keywords: DIPG; H3K27M; epigenetic; histone H3 mutation; mouse model; paediatric high-grade glioma.

Similar articles

See all similar articles

Publication types

LinkOut - more resources

Feedback