Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2019 Dec;98(51):e18273.
doi: 10.1097/MD.0000000000018273.

Contribution of MTR A2756G Polymorphism and MTRR A66G Polymorphism to the Risk of Idiopathic Male Infertility

Affiliations
Free PMC article
Meta-Analysis

Contribution of MTR A2756G Polymorphism and MTRR A66G Polymorphism to the Risk of Idiopathic Male Infertility

Zheng-Ju Ren et al. Medicine (Baltimore). .
Free PMC article

Abstract

Background: Methionine synthase reductase gene (MTRR A66G) polymorphism and methionine synthase gene (MTR A2756G) polymorphism have shown an association with idiopathic male infertility risk in several ethnic populations. However, their small sample sizes and inconsistent outcomes have prevented strong conclusions. We performed a meta-analysis with published studies to evaluate the associations of the 2 single nucleotide polymorphisms (SNPs) and idiopathic male infertility risk.

Methods: A thorough literature search was performed up to Jun 21, 2019 with Medline, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), China Biology Medical literature (CBM), China Science and Technology Journal Database (VIP), and Chinese literature (Wan Fang) databases. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of associations.

Results: Seventeen studies including 3269 cases and 3192 controls met the inclusion criteria. Our meta-analysis showed that the MTR A2756G mutation may contribute to genetic susceptibility to the risk of idiopathic male infertility in Non-Asians, but not to Asian population, whereas the MTRR A66G polymorphism may be unrelated to idiopathic male infertility in both Non-Asian and Asian populations. In the stratified analysis by infertility type, the MTR A2756G polymorphism was a risk factor for both non-obstructive azoospermia (NOA) and oligoasthenoteratozoospermia (OAT) patients. However, the MTRR A66G polymorphism is associated with risk for OAT in Asian, but not in Non-Asian population.

Conclusion: This meta-analysis suggested that the MTR A2756G and MTRR A66G polymorphisms were risk factors for idiopathic male infertility. Studies with larger sample sizes and representative population-based cases and well-matched controls are needed to validate our results.

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flowchart showing the study selection.
Figure 2
Figure 2
Forest plot of the studies assessing the association between MTR A2756G polymorphism and idiopathic male infertility. (A. Allelic model: G vs A; B. additive model: GG vs AA; C. dominant model: GG + AG vs AA; D. recessive model: GG vs AG + AA).
Figure 3
Figure 3
Forest plot of the studies assessing the association between MTRR A66G polymorphism and idiopathic male infertility. (A. Allelic model: G vs A; B. additive model: GG vs AA; C. dominant model: GG + AG vs AA; D. recessive model: GG vs AG + AA).
Figure 4
Figure 4
Funnel plots for the MTR A2756G polymorphism and idiopathic male infertility. (A. Allelic model: G vs A; B. additive model: GG vs AA; C. dominant model: GG + AG vs AA; D. recessive model: GG vs AG + AA).
Figure 5
Figure 5
Funnel plots for the MTRR A66G polymorphism and idiopathic male infertility. (A. Allelic model: G vs A; B. additive model: GG vs AA; C. dominant model: GG + AG vs AA; D. recessive model: GG vs AG + AA).
Figure 6
Figure 6
Sensitivity analysis diagram for each study used to assess the relative risk estimates for the MTR A2756G polymorphism and idiopathic male infertility. (A. Allelic model: G vs A; B. additive model: GG vs AA; C. dominant model: GG + AG vs AA; D. recessive model: GG vs AG + AA).
Figure 7
Figure 7
Sensitivity analysis diagram for each study used to assess the relative risk estimates for the MTRR A66G polymorphism and idiopathic male infertility. (A. Allelic model: G vs A; B. additive model: GG vs AA; C. dominant model: GG + AG vs AA; D. recessive model: GG vs AG + AA).

Similar articles

See all similar articles

References

    1. Razavi SM, Sabbaghian M, Jalili M, et al. Comprehensive functional enrichment analysis of idiopathic male infertility. Sci Rep 2017;7:15778. - PMC - PubMed
    1. Sharma RK, Said T, Agarwal A. Sperm DNA damage and its clinical relevance in assessing reproductive outcome. Asian J Androl 2004;6:139–48. - PubMed
    1. Liu L, Cai Z, Leng H, et al. [Association of MTHFR C677T and MS A2756G polymorphism with semen quality]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2012;37:1054–9. - PubMed
    1. Chang J, Pan F, Tang Q, et al. eNOS gene T786C, G894T and 4a4b polymorphisms and idiopathic male infertility susceptibility: a meta-analysis. Andrologia 2017;4:49. - PubMed
    1. Miyamoto T, Minase G, Shin T, et al. Human idiopathic male infertility and its genetic causes. Reprod Med Biol 2017;16:81–8. - PMC - PubMed

Publication types

MeSH terms

Substances

Feedback