Effects of epinephrine on retinal and choroidal blood flow through different routes of drug administration

Ophthalmic Res. 1988;20(5):293-7. doi: 10.1159/000266728.

Abstract

Epinephrine (1, 3 and 10 micrograms/kg) was found to increase retinal and choroidal blood flow (22, 49 and 67%) when it was administered intravenously. The increase in retinal and choroidal blood flow coincided well with the increase in systemic blood pressure (44, 65 and 96%, respectively). When epinephrine (2%) was instilled to the eyes topically the retinal and choroidal blood flow decreased (15%) while systemic blood pressure remained unchanged. It is suggested that the decrease in retinal and choroidal blood flow by topical epinephrine could be the cause of epinephrine maculopathy reported previously. L-Timolol (0.25%, topically) did not affect retinal and choroidal blood flow significantly.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Topical
  • Animals
  • Blood Pressure / drug effects
  • Choroid / blood supply*
  • Dose-Response Relationship, Drug
  • Epinephrine / administration & dosage
  • Epinephrine / pharmacology*
  • Female
  • Injections, Intravenous
  • Rabbits
  • Regional Blood Flow / drug effects
  • Retinal Vessels / drug effects*
  • Timolol / administration & dosage
  • Timolol / pharmacology

Substances

  • Timolol
  • Epinephrine