Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane sesquiterpenoids, including three new compounds (1-3), were isolated from wood extracts of Santalum album (Santalaceae). Structures of compounds 1-3 were elucidated by spectral data to have a cadinane skeleton with an aromatic ring. Of the eight compounds isolated, compound 4, identified as mansonone I, was found to be active against TOP, having an IC50 of 1.2 μM.
Keywords: Cadinane; Santalum album; Sesquiterpene; Wnt.
A rare type of sesquiterpene and β-santalol derivatives from Santalum album and their cytotoxic activities.Chem Pharm Bull (Tokyo). 2014;62(12):1192-9. doi: 10.1248/cpb.c14-00457. Chem Pharm Bull (Tokyo). 2014. PMID: 25450628
New cadinane sesquiterpenoids from Mikania micrantha.Nat Prod Res. 2019 Mar 19:1-8. doi: 10.1080/14786419.2019.1586691. Online ahead of print. Nat Prod Res. 2019. PMID: 30887848
Isolation of cDNAs and functional characterisation of two multi-product terpene synthase enzymes from sandalwood, Santalum album L.Arch Biochem Biophys. 2008 Sep 1;477(1):121-30. doi: 10.1016/j.abb.2008.05.008. Epub 2008 May 27. Arch Biochem Biophys. 2008. PMID: 18541135
Screening for natural products that affect Wnt signaling activity.J Nat Med. 2019 Sep;73(4):697-705. doi: 10.1007/s11418-019-01320-9. Epub 2019 May 30. J Nat Med. 2019. PMID: 31147959 Free PMC article. Review.
Sandalwood: basic biology, tissue culture, and genetic transformation.Planta. 2016 Apr;243(4):847-87. doi: 10.1007/s00425-015-2452-8. Epub 2016 Jan 8. Planta. 2016. PMID: 26745967 Review.