Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy

J Neuroimmunol. 2020 Feb 15;339:577139. doi: 10.1016/j.jneuroim.2019.577139. Epub 2019 Dec 16.

Abstract

To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with those of healthy Japanese controls. All IgG4 anti-NF155 antibody-positive CIDP patients exclusively carried either HLA-DRB1*15:01-DRB5*01:01-DQA1*01:02-DQB1*06:02 or -(A*24:02)-B*52:01-C*12:02-DRB1*15:02-DRB5*01:02-DQA1*01:03-DQB1*06:01, resulting in significantly increased HLA-DRB1*15, -DRB1*15:01, -DQB1*06:01/06:02, -DQB1*06:02, and -DRB1*15:01-DQB1*06:02 frequencies compared with healthy Japanese controls. These findings indicate the involvement of specific HLA class II molecules in the pathomechanisms of IgG4 anti-NF155 antibody-positive CIDP.

Keywords: Chronic inflammatory demyelinating polyneuropathy; HLA; Haplotype; IgG4; Neurofascin 155.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Asian People / genetics
  • Autoantibodies / blood
  • Autoantibodies / genetics*
  • Cell Adhesion Molecules / blood
  • Cell Adhesion Molecules / genetics*
  • Female
  • HLA Antigens / blood
  • HLA Antigens / genetics*
  • Haplotypes / genetics*
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / genetics*
  • Male
  • Middle Aged
  • Nerve Growth Factors / blood
  • Nerve Growth Factors / genetics*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / blood
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / genetics*
  • Young Adult

Substances

  • Autoantibodies
  • Cell Adhesion Molecules
  • HLA Antigens
  • Immunoglobulin G
  • NFASC protein, human
  • Nerve Growth Factors