Chemokines in human obesity

Cytokine. 2020 Mar;127:154953. doi: 10.1016/j.cyto.2019.154953. Epub 2019 Dec 19.

Abstract

Obesity and type 2 diabetes have been shown to be associated with chronic inflammation. Despite extensive evidence for inflammatory mediators in the obese patients and multiple clinical trials, the outcome has been disappointing. In murine models recruitment of immune cells during inflammation has been shown to contribute to the chronic inflammation. Clearcut evidence for the differential expression of chemokines that mediate this recruitment is not available. In this short review we discuss the observations on CCL2 and CCL5 in human obesity.

Keywords: Chemokines; Human obesity; Subcutaneous adipose tissues; Visceral adipose tissues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemokine CCL2 / metabolism
  • Chemokine CCL5 / metabolism
  • Chemokines / metabolism*
  • Diabetes Mellitus, Type 2 / metabolism
  • Humans
  • Inflammation / metabolism
  • Obesity / metabolism*

Substances

  • Chemokine CCL2
  • Chemokine CCL5
  • Chemokines