Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD pathophysiology entails chronic inflammation involving innate immune cells including microglia, astrocytes, and other peripheral blood cells. Inflammatory mediators such as cytokines and complements are also linked to AD pathogenesis. Despite increasing evidence supporting the association between abnormal inflammation and AD, no well-established inflammatory biomarkers are currently available for AD. Since many reports have shown that abnormal inflammation precedes the outbreak of the disease, non-invasive and readily available peripheral inflammatory biomarkers should be considered as possible biomarkers for early diagnosis of AD. In this minireview, we introduce the peripheral biomarker candidates related to abnormal inflammation in AD and discuss their possible molecular mechanisms. Furthermore, we also summarize the current state of inflammatory biomarker research in clinical practice and molecular diagnostics. We believe this review will provide new insights into biomarker candidates for the early diagnosis of AD with systemic relevance to inflammation during AD pathogenesis. [BMB Reports 2020; 53(1): 10-19].
Conflict of interest statement
The authors have no conflicting interests.
Influence of Microglia and Astrocyte Activation in the Neuroinflammatory Pathogenesis of Alzheimer's Disease: Rational Insights for the Therapeutic ApproachesMH Ahmad et al. J Clin Neurosci 59, 6-11. PMID 30385170. - ReviewAlzheimer's disease (AD), the most common progressive neurodegenerative disorder is characterized by the formation of extracellular amyloid plaques and intracellular neur …
[Pro-inflammatory Cytokines in Alzheimer's Disease]EC Stamouli et al. Psychiatriki 27 (4), 264-275. PMID 28114090. - ReviewAlzheimer's disease (AD), the most common progressive neurodegenerative disorder in the elderly, is clinically characterized by progressive impairment of cognitive functi …
Interleukins, Inflammation, and Mechanisms of Alzheimer's DiseaseD Weisman et al. Vitam Horm 74, 505-30. PMID 17027528. - ReviewAlzheimer's disease (AD) is the most common progressive neurodegenerative form of dementia in the elderly and is characterized neuropathologically by neurofibrillary tang …
Neuroinflammation in Alzheimer's DiseaseF Zhang et al. Neuropsychiatr Dis Treat 11, 243-56. PMID 25673992. - ReviewAmyloid-β plaques and neurofibrillary tangles are the main neuropathological hallmarks in Alzheimer's disease (AD), the most common cause of dementia in the elderly. Howe …
Inflammation as a Central Mechanism in Alzheimer's DiseaseJW Kinney et al. Alzheimers Dement (N Y) 4, 575-590. PMID 30406177. - ReviewAlzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaque …