[Cardiac dysfunction and the obstructive sleep apnoea syndrome]

Abstract

Introduction: Cardiac insufficiency affects nearly 2% of the population with increased morbidity/mortality despite advances in therapeutic management. The sleep apnoea syndrome (SAS) is a risk factor for, and cause of aggravation of, myocardial dysfunction.

Background: SAS is found in 70% of patients with chronic cardiac failure, 65% of patients with refractory hypertension, 60% of patients with cerebro-vascular accidents and 50% of patients with atrial fibrillation. The associated cardiovascular mortality is multiplied by a factor of 2 to 3. The pathophysiological mechanisms are intermittent nocturnal hypoxia, variations in CO₂ levels, variations in intrathoracic pressure and repeated arrousals from sleep, concurrent with sympathetic hyperactivity, endothelial dysfunction and systemic inflammation.

Conclusions: SAS and cardiological management in patients presenting with myocardial dysfunction should be combined. It is necessary to pursue the scientific investigations with the aim of determining a precise care pathway and the respective places of each of the cardiological and pulmonary measures.

Keywords: Arterial hypertension; Cardiac insufficiency; Continuous positive pressure ventilation; Hypertension artérielle; Insuffisance cardiaque; Servo-assisted ventilation.; Sleep apnoea syndrome; Syndrome d’apnée du sommeil; Ventilation en pression positive continue; Ventilation servo-assistée.