Neurobiology of Aggressive Behavior-Role of Autoantibodies Reactive With Stress-Related Peptide Hormones

Henning Vaeroy; Frida Schneider; Sergueï O Fetissov

doi:10.3389/fpsyt.2019.00872

Neurobiology of Aggressive Behavior-Role of Autoantibodies Reactive With Stress-Related Peptide Hormones

Front Psychiatry. 2019 Dec 4:10:872. doi: 10.3389/fpsyt.2019.00872. eCollection 2019.

Authors

Henning Vaeroy¹, Frida Schneider¹, Sergueï O Fetissov²

Affiliations

¹ Department of Psychiatric Research, Akershus University Hospital, Nordbyhagen, Norway.
² Inserm UMR1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, University of Rouen Normandy, Rouen, France.

Abstract

Adrenocorticotropic hormone together with arginine vasopressin and oxytocin, the neuropeptides regulating the stress response and the hypothalamic-pituitary-adrenal axis activity, are known to modulate aggressive behavior. The functional role of the adrenocorticotropic hormone immunoglobulin G autoantibodies in peptidergic signaling and motivated behavior, including aggression, has been shown in experimental and in vitro models. This review summarizes some experimental data implicating autoantibodies reactive with stress-related peptides in aggressive behavior.

Keywords: adrenocorticotropic hormone; autoantibodies; cortisol; epitopes; human aggression; hypothalamic-pituitary-adrenal axis; oxytocin; vasopressin.

Publication types

Review