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. 2020 Jan 24;83(1):99-104.
doi: 10.1021/acs.jnatprod.9b00878. Epub 2019 Dec 23.

Structurally Diverse Meroterpenoids from a Marine-Derived Aspergillus sp. Fungus

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Structurally Diverse Meroterpenoids from a Marine-Derived Aspergillus sp. Fungus

Huiling Wen et al. J Nat Prod. .

Abstract

Three new meroterpenoids, asperaustins A-C (1-3), and seven known analogues (4-10) were isolated from a marine-derived Aspergillus sp. fungus. The structures and absolute configurations of these new compounds were unequivocally determined by extensive spectroscopic analyses and single-crystal X-ray diffraction analyses. Asperaustin A (1) possesses an unusual spiro[4.5]deca-3,6-dien-2-one moiety with a unique 5/6/6/6/5 pentacyclic skeleton. The absolute configurations of austinoneol A (7) and precalidodehydroaustin (9) were determined by single-crystal X-ray diffraction analyses using Cu Kα radiation for the first time.

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