The impact of active vitamin D administration on the clinical outcomes of acne vulgaris

J Dermatolog Treat. 2021 Nov;32(7):756-761. doi: 10.1080/09546634.2019.1708852. Epub 2020 Jan 3.


Acne vulgaris is one of the most common chronic inflammatory skin disorder affecting millions of people worldwide. Vitamin D deficiency has a role in various inflammatory skin diseases as acne. This study aimed to investigate the serum level of 25 hydroxy vitamin D in acne patients and to assess the efficacy and safety of active vitamin D in management of acne. This study was conducted on 100 patients with acne and 100 healthy controls, then the 100 acne patients were randomized to either the study group that received 0.25ug alfacalcidol daily or the placebo group that received oral placebo during the 3 months study period. Serum levels of 25-hydroxy-vitamin D were significantly lower in acne patients than in healthy control and were inversely correlated to the severity of acne. After alfacalcidol administration, the study group showed significant higher level of 25(OH) D levels (p < .05) compared to placebo group. In addition, median serum level of IL6 and TNFα significantly decreased (p < .05) in the study group in comparison to placebo group and as compared to their baseline results. Acne patients are more commonly to have vitamin D deficiency as compared to healthy people and hence, alfacalcidol might have a beneficial role in the acne management with no reported side effects.

Keywords: Acne vulgaris; active Vitamin D; inflammation; interleukin 6; tumor necrosis factor alpha.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acne Vulgaris* / drug therapy
  • Humans
  • Skin
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency* / complications
  • Vitamin D Deficiency* / drug therapy


  • Vitamin D