Down but not out

Elife. 2019 Dec 23:8:e53363. doi: 10.7554/eLife.53363.

Abstract

A new study in monkeys suggests that treating HIV infection early with antiretroviral therapy reduces the number of latent viruses, but has little impact on viral reactivation when treatment stops.

Keywords: HIV; Monkeys; SIV; antiretroviral therapy; infectious disease; latent reservoir; microbiology; viral latency; virus.

MeSH terms

  • Animals
  • Antiretroviral Therapy, Highly Active / methods
  • Antirheumatic Agents / pharmacology*
  • Antirheumatic Agents / therapeutic use
  • Disease Models, Animal
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • Haplorhini
  • Humans
  • Macaca mulatta
  • Simian Acquired Immunodeficiency Syndrome
  • Simian Immunodeficiency Virus / drug effects
  • Time Factors
  • Virus Latency / drug effects*

Substances

  • Antirheumatic Agents