ORP5 regulates PI(4)P on the lipid droplet: Novel players on the monolayer

Mike F Renne; Brooke M Emerling

doi:10.1083/jcb.201912010

ORP5 regulates PI(4)P on the lipid droplet: Novel players on the monolayer

J Cell Biol. 2020 Jan 6;219(1):e201912010. doi: 10.1083/jcb.201912010.

Authors

Mike F Renne¹, Brooke M Emerling²

Affiliations

¹ Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
² Sanford Burnham Prebys Medical Discovery Institute, Cancer Metabolism and Signaling Networks Program, La Jolla, CA.

Abstract

How the distinct lipid composition of organelles is determined and maintained is still poorly understood. In this issue, Du et al. (2019. J. Cell Biol.https://doi.org/10.1083/jcb.201905162) show that the lipid transfer protein ORP5 functions at ER-LD contact sites, regulating lipid droplet levels of phosphatidylserine and phosphatidylinositol-4-phosphate.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Lipid Droplets*
Mitochondrial Membranes*
Phosphatidylserines

Substances

Phosphatidylserines