[Research Progress of Effect of Artemisinin Family Drugs on T Lymphocytes Immunomodulation]

Zhongguo Zhong Yao Za Zhi. 2019 Nov;44(22):4992-4999. doi: 10.19540/j.cnki.cjcmm.20190618.401.
[Article in Chinese]

Abstract

Artemisinin was isolated from traditional Chinese herb Artemisia annua for treating malaria. A series of derivatives,like dihydroartemisinin,artesunate,artemether,artether,had the same core chemical structure,and sesquiterpene lactone containing peroxide bridge constitute the basic chemical structure. Besides anti-malaria,artemisinin family drugs were found to ameliorate many different diseases,which have attracted wide attention in recent years. Among different diseases,artemisinin family drugs were found to have T lymphocytes immunomodulation effects,including activation,proliferation,differentiation,apoptosis and subsets function. Because T cell immunologic response is the key point of many diseases,and impact the pathogenic process,therapeutic effect and prognosis,the drug studies with it as the target have become hotspots in recent years. Studies of artemisinin family drug on T cell immunomodulation were still at the initial stage and involved in different disease; furthermore,T cell immune process involves complicated molecular mechanism,it is imperative to summarize the advance of current studies for further systematic explanation and exploration of their characteristics and mechanisms. This article will summarize the research progress of artemisinin family drugs for malaria,autoimmune disease,hypersensitivity reaction,tumor,schistosomiasis and AIDS relating to T cell immune modulation,so as to provide basic and professional reference for related research and application.

Keywords: T lymphocytes; adaptive immunity; artemisinin; immune modulation; immunosuppression.

MeSH terms

  • Antimalarials*
  • Artemisia annua*
  • Artemisinins / pharmacology*
  • Immunomodulation*
  • T-Lymphocytes*

Substances

  • Antimalarials
  • Artemisinins