Postoperative Dexmedetomidine-Induced Polyuria in a Patient With Schizophrenia: A Case Report

A A Pract. 2020 Mar 1;14(5):131-133. doi: 10.1213/XAA.0000000000001162.


We present a patient with schizophrenia who developed dexmedetomidine-induced polyuria after superficial parotidectomy. Two hours after starting the dexmedetomidine infusion, urine output increased from a baseline rate of 80 mL/h to a 7-hour average rate of 400 mL/h (range, 280-560 mL/h), the serum sodium concentration increased from 132 to 139 mEq/L, and urine-specific gravity was 1.006. Following dexmedetomidine discontinuation, the urine output decreased to an average of 66 mL/h (range, 40-100 mL/h). Close monitoring of urine output and serum sodium concentration may be indicated during dexmedetomidine infusion.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Dexmedetomidine / adverse effects*
  • Humans
  • Infusions, Intravenous
  • Male
  • Monitoring, Physiologic
  • Parotid Gland / surgery*
  • Polyuria / chemically induced*
  • Postoperative Complications / chemically induced
  • Schizophrenia / complications*
  • Sodium / blood
  • Sodium / urine


  • Dexmedetomidine
  • Sodium