Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental disorder with considerable clinical heterogeneity. With no cure for the disorder, treatments commonly center around speech and behavioral therapies to improve the characteristic social, behavioral, and communicative symptoms of ASD. Gastrointestinal disturbances are commonly encountered comorbidities that are thought to be not only another symptom of ASD but to also play an active role in modulating the expression of social and behavioral symptoms. Therefore, nutritional interventions are used by a majority of those with ASD both with and without clinical supervision to alleviate gastrointestinal and behavioral symptoms. Despite a considerable interest in dietary interventions, no consensus exists regarding optimal nutritional therapy. Thus, patients and physicians are left to choose from a myriad of dietary protocols. This review, summarizes the state of the current clinical and experimental literature on nutritional interventions for ASD, including gluten-free and casein-free, ketogenic, and specific carbohydrate diets, as well as probiotics, polyunsaturated fatty acids, and dietary supplements (vitamins A, C, B6, and B12; magnesium and folate).
Keywords: Autism spectrum disorder (ASD); casein-free diet; dietary supplements; gluten-free diet; ketogenic diet; polyunsaturated fatty acids; probiotics; specific carbohydrate diet.
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Current Nutritional Approaches in Managing Autism Spectrum Disorder: A ReviewH Cekici et al. Nutr Neurosci 22 (3), 145-155. PMID 28762296. - ReviewThe research put forward that in individuals with ASD, while gluten-free/casein-free and ketogenic diets, camel milk, curcumin, probiotics, and fermentable foods can play …
Nutritional and Dietary Interventions for Autism Spectrum Disorder: A Systematic ReviewN Sathe et al. Pediatrics 139 (6). PMID 28562286. - ReviewThere is little evidence to support the use of nutritional supplements or dietary therapies for children with ASD.
[Substitutive and Dietetic Approaches in Childhood Autistic Disorder: Interests and Limits]H Hjiej et al. Encephale 34 (5), 496-503. PMID 19068339. - ReviewFirst of all, enzymatic disorders and metabolic errors are those most frequently evoked in the literature. The well-known phenylalanine hydroxylase deficit responsible fo …
How Nutritional Status, Diet and Dietary Supplements Can Affect Autism. A ReviewA Kawicka et al. Rocz Panstw Zakl Hig 64 (1), 1-12. PMID 23789306. - ReviewAutism is a neurodevelopmental disorder with symptoms arising that are apparent throughout the patient's lifespan. Autism Spectrum Disorders (ASD) are characterised by im …
Dietary Interventions for Autism Spectrum Disorder: New Perspectives From the Gut-Brain AxisC Doenyas. Physiol Behav 194, 577-582. PMID 30036560. - ReviewThere is still controversy surrounding the effectiveness of dietary interventions for autism spectrum disorder (ASD), namely the gluten-free/casein free diet and the keto …