Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study

Nutrients. 2019 Dec 23;12(1):50. doi: 10.3390/nu12010050.


This study investigated the effects of collagen hydrolysates (CH) on language cognitive function and brain structure. In this open-label study, 5 g CH was administered once a day for 4 weeks to 30 healthy participants aged 49-63 years. The primary outcome measures were the brain healthcare quotients based on gray matter volume (GM-BHQ) and fractional anisotropy (FA-BHQ). The secondary outcome measures were changes in scores between week 0 and week 4 for word list memory (WLM) and standard verbal paired associate learning (S-PA) tests as well as changes in the physical, mental, and role/social component summary scores of the Short Form-36(SF-36) quality of life instrument. CH ingestion resulted in significant improvements in FA-BHQ (p = 0.0095), a measure of brain structure, as well in scores for the WLM (p = 0.0046) and S-PA (p = 0.0007) tests, which measure cognitive function. There were moderate correlations between the change in WLM score and the change in GM-BHQ (r = 0.4448; Spearman's rank correlation) and between the change in S-PA score and the change in FA-BHQ (r = 0.4645). Daily ingestion of CH changed brain structure and improved language cognitive function.

Keywords: cognitive health; collagen hydrolysate; fractional anisotropy-brain healthcare quotient; gray matter volume-brain healthcare quotient; magnetic resonance imaging; standard verbal paired-associate learning test; word list memory test.

MeSH terms

  • Brain / anatomy & histology*
  • Brain / drug effects*
  • Cognition / drug effects*
  • Collagen / administration & dosage*
  • Female
  • Humans
  • Japan
  • Magnetic Resonance Imaging
  • Male
  • Memory and Learning Tests
  • Middle Aged
  • Protein Hydrolysates / administration & dosage
  • Quality of Life


  • Protein Hydrolysates
  • Collagen