Development and evaluation of a vancomycin dosing nomogram to achieve the target area under the concentration-time curve. A retrospective study

Abstract

Although the superiority of vancomycin dosing based on area under the concentration-time curve (AUC_0-24) over that based on trough concentration has been reported, a dosing strategy to achieve the target AUC_0-24 has yet to be developed. The objective of this study was to develop a convenient useable nomogram for vancomycin dosing to obtain the target AUC_0-24 (400 μg h/mL). The nomogram was pharmacokinetically developed in a retrospective manner. The number of enrolled patients and concentrations was 166 and 309 for development of the nomogram, 99 and 181 for evaluation of the nomogram, respectively. The nomogram was developed as doses per personal body weight corresponding to each range of estimated glomerular filtration rate (eGFR), which was identified to be the covariate for vancomycin clearance by non-linear mixed effect modeling. The nomogram described the surrogate trough concentration for the target AUC_0-24 was calculatedly different for each eGFR range (9.3-15.0 μg/mL). The rate of attainment of therapeutic range using surrogate trough concentration to obtain the target AUC_0-24 was 63.8% in the evaluation period. We have developed and evaluated the first convenient useable nomogram of vancomycin dosing to obtain the target AUC_0-24.

Keywords: Area under the concentration-time curve; Nomogram; Pharmacokinetics; Therapeutic drug monitoring; Vancomycin.