P53 versus inflammation: an update

Cell Cycle. 2020 Jan;19(2):160-162. doi: 10.1080/15384101.2019.1708575. Epub 2019 Dec 27.


Etiologies of human pathophysiology have been associated with states of severe inflammation. The endothelium defender P53 supports cellular functions, by orchestrating anti-inflammatory responses. The purpose of the present article is to provide an update on the mechanisms enforcing the protective actions of P53 in human homeostasis, and to discuss current efforts on the development of new therapies against inflammatory abnormalities.

Keywords: Barrier function; endothelium; growth hormone releasing hormone.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Growth Hormone-Releasing Hormone / metabolism
  • HSP90 Heat-Shock Proteins / antagonists & inhibitors
  • HSP90 Heat-Shock Proteins / metabolism
  • Humans
  • Inflammation / metabolism*
  • Inflammation / pathology*
  • Reactive Oxygen Species / metabolism
  • Tumor Suppressor Protein p53 / metabolism*
  • Unfolded Protein Response


  • HSP90 Heat-Shock Proteins
  • Reactive Oxygen Species
  • Tumor Suppressor Protein p53
  • Growth Hormone-Releasing Hormone