Therapeutic Potential of Hericium erinaceus for Depressive Disorder

Int J Mol Sci. 2019 Dec 25;21(1):163. doi: 10.3390/ijms21010163.


Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects. Hericium erinaceus, also known as Lion's mane mushroom, has been shown to have various health benefits, including antioxidative, antidiabetic, anticancer, anti-inflammatory, antimicrobial, antihyperglycemic, and hypolipidemic effects. It has been used to treat cognitive impairment, Parkinson's disease, and Alzheimer's disease. Bioactive compounds extracted from the mycelia and fruiting bodies of H. erinaceus have been found to promote the expression of neurotrophic factors that are associated with cell proliferation such as nerve growth factors. Although antidepressant effects of H. erinaceus have not been validated and compared to the conventional antidepressants, based on the neurotrophic and neurogenic pathophysiology of depression, H. erinaceus may be a potential alternative medicine for the treatment of depression. This article critically reviews the current literature on the potential benefits of H. erinaceus as a treatment for depressive disorder as well as its mechanisms underlying the antidepressant-like activities.

Keywords: Hericium erinaceus; Lion’s mane mushroom; antidepressant; depression; mood disorders.

Publication types

  • Review

MeSH terms

  • Basidiomycota / chemistry*
  • Basidiomycota / metabolism
  • Biological Products / chemistry
  • Biological Products / therapeutic use*
  • Brain-Derived Neurotrophic Factor / metabolism
  • Clinical Trials as Topic
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / pathology
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / therapeutic use
  • Humans
  • Indoles / chemistry
  • Indoles / isolation & purification
  • Indoles / therapeutic use
  • Mycelium / chemistry
  • Mycelium / metabolism
  • Nerve Growth Factors / metabolism


  • Biological Products
  • Brain-Derived Neurotrophic Factor
  • Diterpenes
  • Indoles
  • Nerve Growth Factors