Renal denervation: Alternative treatment options for hypertension?

Prog Cardiovasc Dis. 2020 Jan-Feb;63(1):51-57. doi: 10.1016/j.pcad.2019.12.007. Epub 2019 Dec 27.


Hypertension affects millions of Americans and has adverse long-term consequences increasing morbidity and mortality. Resistant hypertension (RH) continues to be difficult to treat with medications alone which may be associated with significant side effects. Alternate therapies have been evaluated for treating RH and renal denervation has been investigated extensively. We review the data from renal denervation trials and other novel technologies which are not FDA approved to date.

Keywords: Anti-hypertensive agents; Denervation; Hypertension; Resistant hypertension; Sympathectomy.

Publication types

  • Review

MeSH terms

  • Ablation Techniques* / adverse effects
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure* / drug effects
  • Drug Resistance*
  • Drug Therapy, Combination
  • Humans
  • Hypertension / diagnosis
  • Hypertension / epidemiology
  • Hypertension / physiopathology
  • Hypertension / surgery*
  • Kidney / blood supply*
  • Renal Artery / innervation*
  • Risk Factors
  • Sympathectomy* / adverse effects
  • Treatment Outcome


  • Antihypertensive Agents