Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 2019, 7247238
eCollection

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

Affiliations
Review

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

Qingdong Guan. J Immunol Res.

Abstract

Inflammatory bowel disease (IBD) is a chronic and life-threating inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis of IBD is complex. Recent studies have greatly improved our knowledge of the pathophysiology of IBD, leading to great advances in the treatment as well as diagnosis of IBD. In this review, we have systemically reviewed the pathogenesis of IBD and highlighted recent advances in host genetic factors, gut microbiota, and environmental factors and, especially, in abnormal innate and adaptive immune responses and their interactions, which may hold the keys to identify novel predictive or prognostic biomarkers and develop new therapies.

Conflict of interest statement

The author declares no financial conflict of interest.

Similar articles

See all similar articles

References

    1. Szigethy E., McLafferty L., Goyal A. Inflammatory bowel disease. Child and Adolescent Psychiatric Clinics of North America. 2010;19(2):301–318. doi: 10.1016/j.chc.2010.01.007. - DOI - PubMed
    1. Stokkers P. C., Hommes D. W. New cytokine therapeutics for inflammatory bowel disease. Cytokine. 2004;28(4-5):167–173. doi: 10.1016/j.cyto.2004.07.012. - DOI - PubMed
    1. Korzenik J. R., Podolsky D. K. Evolving knowledge and therapy of inflammatory bowel disease. Nature Reviews Drug Discovery. 2006;5(3):197–209. doi: 10.1038/nrd1986. - DOI - PubMed
    1. Hanauer S. B. Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflammatory Bowel Disease. 2006;12(Suppl 1):S3–S9. doi: 10.1097/01.MIB.0000195385.19268.68. - DOI - PubMed
    1. Ng S. C., Shi H. Y., Hamidi N., et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2018;390(10114):2769–2778. doi: 10.1016/S0140-6736(17)32448-0. - DOI - PubMed

LinkOut - more resources

Feedback