Inflammatory bowel disease (IBD) is a chronic and life-threating inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis of IBD is complex. Recent studies have greatly improved our knowledge of the pathophysiology of IBD, leading to great advances in the treatment as well as diagnosis of IBD. In this review, we have systemically reviewed the pathogenesis of IBD and highlighted recent advances in host genetic factors, gut microbiota, and environmental factors and, especially, in abnormal innate and adaptive immune responses and their interactions, which may hold the keys to identify novel predictive or prognostic biomarkers and develop new therapies.
Copyright © 2019 Qingdong Guan.
Conflict of interest statement
The author declares no financial conflict of interest.
Inflammatory bowel disease: pathogenesis.World J Gastroenterol. 2014 Jan 7;20(1):91-9. doi: 10.3748/wjg.v20.i1.91. World J Gastroenterol. 2014. PMID: 24415861 Free PMC article. Review.
Gut microbiota in the pathogenesis of inflammatory bowel disease.Clin J Gastroenterol. 2018 Feb;11(1):1-10. doi: 10.1007/s12328-017-0813-5. Epub 2017 Dec 29. Clin J Gastroenterol. 2018. PMID: 29285689 Review.
Recent progress on the role of gut microbiota in the pathogenesis of inflammatory bowel disease.J Dig Dis. 2013 Oct;14(10):513-7. doi: 10.1111/1751-2980.12087. J Dig Dis. 2013. PMID: 23848393 Review.
Inflammatory Bowel Disease: A Potential Result from the Collusion between Gut Microbiota and Mucosal Immune System.Microorganisms. 2019 Oct 11;7(10):440. doi: 10.3390/microorganisms7100440. Microorganisms. 2019. PMID: 31614539 Free PMC article. Review.
The interplay between microbes and the immune response in inflammatory bowel disease.J Physiol. 2018 Sep;596(17):3869-3882. doi: 10.1113/JP275396. Epub 2018 Jul 17. J Physiol. 2018. PMID: 29806140 Free PMC article. Review.