Cultivated Escherichia coli diversity in intestinal microbiota of Crohn's disease patients and healthy individuals: Whole genome data

Maria Siniagina; Maria Markelova; Alexander Laikov; Eugenia Boulygina; Dilyara Khusnutdinova; Anastasia Kharchenko; Albina Misbakhova; Tatiana Grigoryeva

doi:10.1016/j.dib.2019.104948

Cultivated Escherichia coli diversity in intestinal microbiota of Crohn's disease patients and healthy individuals: Whole genome data

Data Brief. 2019 Dec 5:28:104948. doi: 10.1016/j.dib.2019.104948. eCollection 2020 Feb.

Authors

Maria Siniagina¹, Maria Markelova¹, Alexander Laikov¹, Eugenia Boulygina¹, Dilyara Khusnutdinova¹, Anastasia Kharchenko¹, Albina Misbakhova², Tatiana Grigoryeva¹

Affiliations

¹ Kazan Federal University, Russian Federation.
² Kazan Medical State University, Russian Federation.

Abstract

Dysbiosis of the gut microbiota in inflammatory bowel disease (IBD) patients is of great interest. It has been reported that Crohn's disease (CD) is associated with a general decrease in microbial diversity [1]. Altered microbial composition and function in CD results in imbalance in host-bacteria interaction and increased immune stimulation [2]. It is shown that microbiota in CD is characterized by increased proportion of E. coli in human gut in contrast to healthy individuals [3]. However, the overall qualitative and quantitative diversity of E. coli strains in CD is not fully understood. Here, we present a dataset of whole-genome sequences of E. coli's.

Keywords: Crohn's disease; Escherichia coli; Human gut microbiota; Whole-genome sequencing.