[Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma]

Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(6):21-4.
[Article in Russian]

Abstract

A total of 84 children were investigated: 15 with bronchial asthma, 41 with combined seizure and bronchial obstruction syndrome, 14 with epilepsy. The kynurenine blood level was found to correlate with seizures. It was highest in epilepsy (5.27 +/- 0.99 nM/ml) together with the lowest dioxygenase activity (0.53 +/- 0.29 nM/ml) as measured with the tryptophane loading. The data suggest that kynurenine being a major tryptophane metabolite plays a role in pathogenesis of convulsive states.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adolescent
  • Asthma / blood*
  • Child
  • Child, Preschool
  • Chronic Disease
  • Epilepsy / blood*
  • Epilepsy / etiology
  • Female
  • Humans
  • Kynurenine / blood*
  • Male
  • Pneumonia / blood
  • Spectrophotometry
  • Tryptophan

Substances

  • Kynurenine
  • Tryptophan