Parkinson's disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research.
Keywords: Gut; Inflammation; Intestinal microbiota; Parkinson’s disease; Protein aggregation.
© The Author(s). 2019.
Conflict of interest statement
Competing interestsThe authors declare that they have no competing interests.
Colonic bacterial composition in Parkinson's disease.Mov Disord. 2015 Sep;30(10):1351-60. doi: 10.1002/mds.26307. Epub 2015 Jul 16. Mov Disord. 2015. PMID: 26179554
Nigral overexpression of α-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome.Neurogastroenterol Motil. 2020 Jan;32(1):e13726. doi: 10.1111/nmo.13726. Epub 2019 Oct 2. Neurogastroenterol Motil. 2020. PMID: 31576631
Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson's Disease.Neurochem Res. 2018 Oct;43(10):1986-1999. doi: 10.1007/s11064-018-2620-x. Epub 2018 Aug 31. Neurochem Res. 2018. PMID: 30171422
Gut Inflammation in Association With Pathogenesis of Parkinson's Disease.Front Mol Neurosci. 2019 Sep 13;12:218. doi: 10.3389/fnmol.2019.00218. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31572126 Free PMC article. Review.
Gut Vibes in Parkinson's Disease: The Microbiota-Gut-Brain Axis.Mov Disord Clin Pract. 2019 Oct 23;6(8):639-651. doi: 10.1002/mdc3.12840. eCollection 2019 Nov. Mov Disord Clin Pract. 2019. PMID: 31745471 Review.