Phentermine Use During First and Second Trimesters Associated with Fetal Stroke

Cureus. 2019 Nov 16;11(11):e6170. doi: 10.7759/cureus.6170.


Phentermine is a sympathomimetic amine used for the short-term weight loss that has been associated with ischemic and hemorrhagic strokes in adults. The effects of this medication on a developing fetus are not well studied. We present the case of a woman who was taking phentermine during the first two trimesters of pregnancy and subsequently delivered a child with bilateral porencephalic cysts likely due to a prenatal stroke.

Keywords: fetal; fetus; in-utero; phentermine; porencephaly; pregnancy; stroke; sympathomimetic; weight loss; weight loss medications.

Publication types

  • Case Reports