Blood pressure, dietary fats, and antioxidants

Am J Clin Nutr. 1988 Nov;48(5):1226-32. doi: 10.1093/ajcn/48.5.1226.


We investigated the association of dietary fatty acids and antioxidants with blood pressure in 722 eastern Finnish men aged 54 y, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study in 1984-86. Men with self-reported hypertension or cerebrovascular disease or under antihypertensive medication were excluded. Allowing for the major anthropometric, dietary, medical, and psychological determinants of blood pressure in multivariate regression analyses, both plasma ascorbic acid (p = 0.0008) and serum selenium (p = 0.0017) concentrations had a moderate, independent inverse association, estimated dietary intake of saturated fatty acids had a positive association (p = 0.013), and estimated dietary intake of linolenic acid had an inverse (p = 0.048) association with the mean resting blood pressure. The marked elevation of blood pressure at the lowest levels of plasma ascorbic acid and serum Se concentrations supports the hypothesis that antioxidants play a role in the etiology of hypertension.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / pharmacology*
  • Ascorbic Acid / blood
  • Blood Pressure*
  • Cohort Studies
  • Coronary Disease / etiology
  • Dietary Fats / administration & dosage
  • Dietary Fats / pharmacology*
  • Fatty Acids / pharmacology
  • Fatty Acids, Unsaturated / pharmacology
  • Finland
  • Humans
  • Male
  • Middle Aged
  • Risk Factors


  • Antioxidants
  • Dietary Fats
  • Fatty Acids
  • Fatty Acids, Unsaturated
  • Ascorbic Acid