Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12

Ziling Mao; Weixuan Wang; Ruixue Su; Gan Gu; Zhi Long Liu; Daowan Lai; Ligang Zhou

doi:10.3390/molecules25010114

Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12

Molecules. 2019 Dec 27;25(1):114. doi: 10.3390/molecules25010114.

Authors

Ziling Mao¹, Weixuan Wang¹, Ruixue Su¹, Gan Gu¹, Zhi Long Liu², Daowan Lai¹, Ligang Zhou¹

Affiliations

¹ Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, China.
² Department of Entomology, College of Plant Protection, China Agricultural University, Beijing 100193, China.

Abstract

Two new decalin/tetramic acid hybrid metabolites, hyalodendrins A (1) and B (2) were isolated from plant endophytic fungus Hyalodendriella sp. Ponipodef12. The structures of the new compounds were elucidated by analysis of the spectroscopic data, including NMR, HRMS and ECD, and by chemical conversion. Compounds 1 and 2 were phomasetin analogues, and both showed potent larvicidal activity against the fourth-instar larvae of Aedes aegypti with the median lethal dose (LC₅₀) values of 10.31 and 5.93 μg/mL, respectively.

Keywords: Hyalodendriella sp.; hyalodendrin; larvicidal activity; plant endophytic fungus; structural elucidation; tetramic acid.

MeSH terms

Aedes / growth & development*
Animals
Ascomycota / chemistry*
Insecticides* / chemistry
Insecticides* / isolation & purification
Insecticides* / pharmacology
Larva / growth & development
Piperazines* / chemistry
Piperazines* / isolation & purification
Piperazines* / pharmacology

Substances

Insecticides
Piperazines
hyalodendrin

Grants and funding

2017YFD0201105 and 2017YFC1600905/National Key R&D Program of China