Absence of detectable chromosomal and molecular abnormalities in monozygotic twins discordant for the Wiedemann-Beckwith syndrome

Am J Med Genet. 1988 Jul;30(3):821-33. doi: 10.1002/ajmg.1320300316.


Monozygotic twins discordant for the Wiedemann-Beckwith syndrome (WBS) were studied by cytogenetic and molecular methods to determine if a genetic lesion could be detected in the affected child. Probes known to be localized on the short arm of chromosome 11 and a low copy-repetitive probe were used. No genetic lesions could be ascertained in normal or affected tissue obtained from the WBS twin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Beckwith-Wiedemann Syndrome / genetics*
  • Chromosomes, Human, Pair 11
  • DNA Probes
  • Diseases in Twins*
  • Female
  • Genetic Markers
  • Humans
  • Infant
  • Phenotype
  • Twins, Monozygotic


  • DNA Probes
  • Genetic Markers