Treatment of acquired nystagmus with botulinum A toxin

Am J Ophthalmol. 1988 Nov 15;106(5):584-6. doi: 10.1016/0002-9394(88)90590-9.


We injected botulinum A toxin into the retrobulbar space of one eye each in two patients who had acquired nystagmus with oscillopsia and decreased vision. After injection of 25 units of botulinum A toxin, visual acuity improved from 20/80 to 20/30 in one patient, and both patients were able to read and watch television. Improved vision lasted from five to 13 weeks. No adverse side effects were observed after a total of five injections in each patient.

Publication types

  • Case Reports

MeSH terms

  • Botulinum Toxins / therapeutic use*
  • Cerebral Infarction / complications
  • Eye
  • Female
  • Humans
  • Injections
  • Middle Aged
  • Nystagmus, Pathologic / complications
  • Nystagmus, Pathologic / drug therapy*
  • Nystagmus, Pathologic / physiopathology
  • Recurrence
  • Vision, Ocular / drug effects
  • Visual Acuity


  • Botulinum Toxins