Abstract
We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels.
MeSH terms
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Animals
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Carboxymethylcellulose Sodium / chemical synthesis
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Carboxymethylcellulose Sodium / metabolism
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Carboxymethylcellulose Sodium / pharmacology*
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Cell Line
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Doxorubicin / toxicity
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Humans
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Hydrogels / chemical synthesis
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Hydrogels / metabolism
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Hydrogels / pharmacology*
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Hydrogen Sulfide / metabolism*
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Leukocyte Elastase / metabolism*
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Oxidative Stress / drug effects
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Oximes / chemical synthesis
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Oximes / metabolism
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Oximes / pharmacology
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Polyethylene Glycols / chemical synthesis
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Polyethylene Glycols / metabolism
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Polyethylene Glycols / pharmacology*
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Protective Agents / chemical synthesis
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Protective Agents / metabolism
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Protective Agents / pharmacology
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Rats
Substances
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Hydrogels
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Oximes
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Protective Agents
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Polyethylene Glycols
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Doxorubicin
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ELANE protein, human
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Leukocyte Elastase
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Carboxymethylcellulose Sodium
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Hydrogen Sulfide