Background: Cannabis was used for cancer patients as early as about 2500 years ago. Experimental studies demonstrated tumor-inhibiting activities of various cannabinoids more than 40 years ago. In view of the status of tetrahydrocannabinol (THC) as a regulated substance, non-psychotomimetic cannabidiol (CBD) is of particular importance.
Objectives: Efficacy of pure CBD in various animal models as well as initial results (case reports) from patients.
Methods: Review of the literature on animal experiments and observations in humans.
Results: Preclinical studies, particularly recent ones, including numerous animal models of tumors, unanimously suggest the therapeutic efficacy of CBD. In isolated combination studies, synergistic effects were generally observed. In addition, CBD may potentially play a role in the palliative care of patients, especially concerning symptoms such as pain, insomnia, anxiety, and depression. Further human studies are warranted.
Keywords: Cancer; Cannabidiol (CBD); Cannabinoids; Malignant disease; Tumors.
The Use of Cannabis in Supportive Care and Treatment of Brain TumorR Likar et al. Neurooncol Pract 4 (3), 151-160. PMID 31385997. - ReviewCannabinoids are multitarget substances. Currently available are dronabinol (synthetic delta-9-tetrahydrocannabinol, THC), synthetic cannabidiol (CBD) the respective subs …
Cannabidiol: Pharmacology and Potential Therapeutic Role in Epilepsy and Other Neuropsychiatric DisordersO Devinsky et al. Epilepsia 55 (6), 791-802. PMID 24854329. - ReviewTo present a summary of current scientific evidence about the cannabinoid, cannabidiol (CBD) with regard to its relevance to epilepsy and other selected neuropsychiatric …
A Randomised Controlled Trial of Vaporised Δ 9-tetrahydrocannabinol and Cannabidiol Alone and in Combination in Frequent and Infrequent Cannabis Users: Acute Intoxication EffectsN Solowij et al. Eur Arch Psychiatry Clin Neurosci 269 (1), 17-35. PMID 30661105. - Randomized Controlled TrialAccess to cannabis and cannabinoid products is increasing worldwide for recreational and medicinal use. Two primary compounds within cannabis plant matter, Δ9- …
Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ 9-TetrahydrocannabinolDL Boggs et al. Neuropsychopharmacology 43 (1), 142-154. PMID 28875990. - ReviewThe plant Cannabis sativa, commonly called cannabis or marijuana, has been used for its psychotropic and mind-altering side effects for millennia. There has been growing …
Cannabis sativa L. And Nonpsychoactive Cannabinoids: Their Chemistry and Role Against Oxidative Stress, Inflammation, and CancerF Pellati et al. Biomed Res Int 2018, 1691428. PMID 30627539. - ReviewIn the last decades, a lot of attention has been paid to the compounds present in medicinal Cannabis sativa L., such as Δ9-tetrahydrocannabinol (Δ9 …