Neuromelanin in the substantia nigra of adult horses

Anat Anz. 1988;166(1-5):53-61.


The structure and histochemical properties of neuromelanin in the Substantia nigra of the horse were studied by light and electron microscopy. Morphological, histochemical and cytochemical evidences showed the presence of a melanin component in some pigment granules, even if a large quantity of granules displayed only the properties of lipofuscins. Pigment formation in the neurons of the Substantia nigra of the horse may take place through the tyrosine-tyrosinase enzymatic pathway, as shown by positive Dopa-reaction. The results obtained were discussed in reference to the possible use of melanin as a marker for catecholaminergic neurons in the brainstem of the horse.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Female
  • Histocytochemistry
  • Horses / anatomy & histology*
  • Macaca nemestrina
  • Melanins / analysis*
  • Microscopy, Electron
  • Neurons / analysis*
  • Neurons / ultrastructure
  • Substantia Nigra / analysis*
  • Substantia Nigra / ultrastructure


  • Melanins
  • neuromelanin