Objective: The objective of the study was to report on the internal consistency reliability and discriminant, concurrent and construct validity of the Pediatric Quality of Life Inventory™ (PedsQL™) Cognitive Functioning Scale as a brief generic cognitive functioning measure in youth with epilepsy.
Methods: The 6-item PedsQL™ Cognitive Functioning Scale and 23-item PedsQL™ 4.0 Generic Core Scales were completed by 221 pediatric patients ages 5-18 years with epilepsy and 336 parents of patients ages 2-18 years in a national field test study for the PedsQL™ Epilepsy Module. Parents also completed the 86-item Behavior Rating Inventory of Executive Function (BRIEF), a widely validated measure of executive functioning.
Results: The PedsQL™ Cognitive Functioning Scale evidenced excellent reliability (patient self-report α = 0.88; parent proxy-report α = 0.96), distinguished between youth with epilepsy and an age, gender, and race/ethnicity-matched healthy sample supporting discriminant validity with large effect sizes (~20-30 point score differences, P < 0.001), and demonstrated concurrent and construct validity, respectively, through large effect size intercorrelations with the BRIEF (Behavioral Regulation Index, Metacognition Index, Global Executive Composite Summary Scores rs = 0.43-0.67, P < 0.001) and the PedsQL™ Generic Core Scales (Total Scale Scores rs = 0.67-0.74, P < 0.001). Minimal clinically important difference (MCID) scores ranged from 5.92 to 8.80.
Conclusions: The PedsQL™ Cognitive Functioning Scale demonstrated excellent internal consistency reliability, discriminant, concurrent, and construct validity in youth with epilepsy and may be suitable as a brief generic patient-reported outcome (PRO) measure for clinical research, clinical trials, and routine clinical practice in pediatric epilepsy.
Keywords: Cognitive functioning; Epilepsy; Executive functioning; Patient-reported outcomes; Pediatrics; PedsQL.
Copyright © 2019. Published by Elsevier Inc.
Conflict of interest statement
Declaration of competing interest Dr. Varni holds the copyright and the trademark for the PedsQL™ and receives financial compensation from the Mapi Research Trust, which is a nonprofit research institute that charges distribution fees to for-profit companies that use the Pediatric Quality of Life Inventory™. The other authors report no competing interest related to this study.
PedsQL™ Cognitive Functioning Scale in pediatric liver transplant recipients: feasibility, reliability, and validity.Qual Life Res. 2011 Aug;20(6):913-21. doi: 10.1007/s11136-010-9823-1. Epub 2010 Dec 24. Qual Life Res. 2011. PMID: 21184184 Free PMC article.
PedsQL™ Multidimensional Fatigue Scale in sickle cell disease: feasibility, reliability, and validity.Pediatr Blood Cancer. 2014 Jan;61(1):171-7. doi: 10.1002/pbc.24776. Epub 2013 Sep 13. Pediatr Blood Cancer. 2014. PMID: 24038960 Free PMC article. Clinical Trial.
The Chinese version of the Pediatric Quality of Life Inventory™ (PedsQL™) 3.0 Asthma Module: reliability and validity.Health Qual Life Outcomes. 2011 Aug 7;9:64. doi: 10.1186/1477-7525-9-64. Health Qual Life Outcomes. 2011. PMID: 21819618 Free PMC article.
The PedsQL™ Oral Health Scale: feasibility, reliability and validity of the Brazilian Portuguese version.Health Qual Life Outcomes. 2012 Apr 24;10:42. doi: 10.1186/1477-7525-10-42. Health Qual Life Outcomes. 2012. PMID: 22531004 Free PMC article.
PedsQL™ sickle cell disease module: feasibility, reliability, and validity.Pediatr Blood Cancer. 2013 Aug;60(8):1338-44. doi: 10.1002/pbc.24491. Epub 2013 Feb 25. Pediatr Blood Cancer. 2013. PMID: 23441057 Free PMC article. Clinical Trial.