Guidelines for Thrombolytic Therapy for Frostbite

J Burn Care Res. 2020 Jan 30;41(1):176-183. doi: 10.1093/jbcr/irz148.


The data are insufficient to support standardized treatment of all patients with frostbite with thrombolytic therapy. The following guidelines, however, should be applied to all patients with cyanosis persisting proximal to the distal phalanx (Grade 3 or 4 frostbite injury) and demonstrated loss of perfusion at or proximal to the middle phalanx immediately after rewarming.

Publication types

  • Review

MeSH terms

  • Cyanosis / etiology
  • Cyanosis / therapy*
  • Finger Injuries / etiology
  • Finger Injuries / therapy*
  • Frostbite / complications
  • Frostbite / therapy*
  • Humans
  • Practice Guidelines as Topic
  • Rewarming
  • Thrombolytic Therapy*
  • Toes / injuries*