An Unsuccessful Attempt to Confirm the Occurrence of 4'-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root

Planta Med. 2020 Oct;86(15):1133-1139. doi: 10.1055/a-1078-5195. Epub 2020 Jan 3.


The lignan 4'-O-β- d-glucosyl-9-O-(6″-deoxysaccharosyl)olivil had previously been discovered in a methanolic extract of valerian root (Valeriana officinalis agg.) and characterized as a potent partial agonist at the A1 adenosine receptors. Today, countless scientific sources, webpages, and press articles mention this compound and discuss it as an active constituent for the sedative effect of this herbal drug. As no second report confirmed the occurrence of this lignan in valerian root during the 20 years since its first description in 1998, we intended to re-prove its presence by means of LCMS using other genuine or added lignans as a quantitative benchmark. Whilst those lignans were clearly detectable in methanolic valerian extracts of all six investigated batches of valerian root, no positive proof of 4'-O-β- d-glucosyl-9-O-(6″-deoxysaccharosyl)olivil was achieved. Our result suggests that this compound does not occur regularly in valerian root in the amounts expected from the single report on the occurrence of this compound.

MeSH terms

  • Hypnotics and Sedatives
  • Lignans*
  • Plant Extracts
  • Plant Roots
  • Valerian*


  • Hypnotics and Sedatives
  • Lignans
  • Plant Extracts
  • olivil