Two Cases of Interleukin-7-Deficient Generalized Verrucosis

Hideyuki Kosumi; Ken Natsuga; Shota Takashima; Toshinari Miyauchi; Yi-Ting Huang; Toshifumi Nomura; Teruki Yanagi; Hsin-Yu Huang; Frank Po-Chao Chiu; Peng-Chieh Chen; Chao-Kai Hsu; Hiroshi Shimizu

doi:10.1093/cid/ciz1240

Two Cases of Interleukin-7-Deficient Generalized Verrucosis

Clin Infect Dis. 2020 Sep 12;71(6):1561-1563. doi: 10.1093/cid/ciz1240.

Authors

Affiliations

¹ Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
² School of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
³ Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁴ International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan.
⁵ Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

PMID: 31900472
DOI: 10.1093/cid/ciz1240

Abstract

We report 2 generalized verrucosis (GV) patients homozygous for a novel mutation in the start codon of IL7. Unlike the previous report in which IL-7 deficiency accompanied CD4 T lymphocytopenia, circulating CD4 T cells were not depleted in one of our patients, suggesting a GV pathogenesis other than poor T-cell development.

Keywords: generalized verrucosis; human papillomavirus; interleukin-7.

Publication types

Case Reports

MeSH terms

Alphapapillomavirus
CD4-Positive T-Lymphocytes*
Female
Homozygote
Humans
Interleukin-7 / genetics*
Male
Middle Aged
Warts / genetics*
Warts / virology

Substances

Interleukin-7