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, 28 (6), 720-726

B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients With Myasthenia Gravis


B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients With Myasthenia Gravis

Young Gi Min et al. Exp Neurobiol.


Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorders mediated by various autoantibodies. Although most patients with MG require chronic immunosuppressive treatment to control disease activity, appropriate surveillance biomarkers that monitor disease activity or potential toxicity of immunosuppressants are yet to be developed. Herein, we investigated quantitative distribution of peripheral blood B cell subsets and transcriptional profiles of memory B cells (CD19+ CD27+) in several subgroups of MG patients classified according to the Myasthenia Gravis Foundation of America (MGFA) Clinical Classification. This study suggests potential immunologic B-cell markers that may guide treatment decision in future clinical settings.

Keywords: B-lymphocytes; Biomarkers; Flow cytometry; Myasthenia gravis; Transcriptome.


Fig. 1
Fig. 1
Box plot representing B cell subset frequencies in 4 groups.

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    1. Lindstrom JM, Seybold ME, Lennon VA, Whittingham S, Duane DD. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value. Neurology. 1976;26:1054–1059. doi: 10.1212/WNL.26.11.1054. - DOI - PubMed
    1. Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A, Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med. 2001;7:365–368. doi: 10.1038/85520. - DOI - PubMed
    1. Higuchi O, Hamuro J, Motomura M, Yamanashi Y. Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis. Ann Neurol. 2011;69:418–422. doi: 10.1002/ana.22312. - DOI - PubMed
    1. Gasperi C, Melms A, Schoser B, Zhang Y, Meltoranta J, Risson V, Schaeffer L, Schalke B, Kröger S. Anti-agrin autoantibodies in myasthenia gravis. Neurology. 2014;82:1976–1983. doi: 10.1212/WNL.0000000000000478. - DOI - PubMed
    1. Romi F, Suzuki S, Suzuki N, Petzold A, Plant GT, Gilhus NE. Anti-voltage-gated potassium channel Kv1.4 antibodies in myasthenia gravis. J Neurol. 2012;259:1312–1316. doi: 10.1007/s00415-011-6344-y. - DOI - PubMed