[Linezolid-induced lactic acidosis - a brief overview with a case report]

Klin Mikrobiol Infekc Lek. 2019 Sep;25(3):92-96.
[Article in Czech]

Abstract

Lactic acidosis is a rare but serious adverse event linked to treatment with linezolid, an oxazolidinone antibiotic. Presented is a case of a 67-year-old man treated for 26 days with linezolid for staphylococcal osteomyelitis of the right foot with subsequent sepsis. During the course of treatment, severe lactic acidosis developed, requiring hospitalization in an intensive care unit. The likely mechanism of this potentially life-threatening complication is discussed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acidosis, Lactic* / diagnosis
  • Acidosis, Lactic* / etiology
  • Acidosis, Lactic* / pathology
  • Aged
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use
  • Humans
  • Linezolid / adverse effects
  • Male
  • Osteomyelitis* / complications
  • Osteomyelitis* / drug therapy
  • Osteomyelitis* / etiology
  • Oxazolidinones*
  • Sepsis* / etiology
  • Staphylococcal Infections* / complications
  • Staphylococcal Infections* / drug therapy
  • Staphylococcal Infections* / etiology
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Oxazolidinones
  • Linezolid