Abstract
Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer's disease and its potential as a lead compound in clinical applications.
Keywords:
Alzheimer’s disease; clinical directions; mechanistic insights; polyphenols; quercetin.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Acetylcholinesterase / metabolism
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Alzheimer Disease / diet therapy
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Alzheimer Disease / drug therapy*
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Alzheimer Disease / metabolism
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Alzheimer Disease / prevention & control
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Amyloid beta-Peptides / antagonists & inhibitors
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Amyloid beta-Peptides / metabolism
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Animals
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / pharmacology*
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Cholinesterase Inhibitors / therapeutic use
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Humans
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacology*
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Neuroprotective Agents / therapeutic use
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Oxidative Stress / drug effects
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Protein Aggregates / drug effects
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Quercetin / chemistry
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Quercetin / pharmacology*
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Quercetin / therapeutic use*
Substances
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Amyloid beta-Peptides
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Antioxidants
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Cholinesterase Inhibitors
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Neuroprotective Agents
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Protein Aggregates
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Quercetin
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Acetylcholinesterase